So, in Vista, I store my pictures in various folders, usually on the desktop, as I take them off of my camera. Once a month or so, I sort them and move them to the "my pictures" folder. Anyway, I've had several folders of pics that I've opened and used (e.g. uploading to facebook) successfully before, then when I go back to look at them, they will not open in any program on this or any other computer. They still show up with the proper filename and size; they just won't open. Some of them even show a thumbnail in their respective folder. For example, double-clicking one of the problem images opens Windows Photo Gallery with the message "Photo Gallery can't open this picture or video. The file format is not supported, or you don't have the latest updates to Photo Gallery."