Just read an article by Ed Sanow on his top ten self defense loads. Since this question has been asked before I will post the list. Fed .40 S&W 155 grain hydra shock 97% One shot stops Fed .357 mag 125 JHP 96 Fed .45 acp 230 grain hydra shock 96 rem .45 acp 185 grain golden saber 95 fed 9mm 115 grain jhp +P+ 9bple 93 Cor bon .40 S&W 135 JHP 92 Win .44 mag 210 grain silvertip 90 Triton .357 sig 125 grain rainier JHP 91 Win 41 mag 175 grain Silvertip 90 Fed .40 S&W 180 grain Hydra shock 90 Notice the hydra shock made the list more than any other bullet. Here is what he had to say about frangibles. "Controversial perhaps, but also missing from my list are all the frangible defensive loads like the glaser safety slug, magsafe, and cor-bon beesafe. These loads are extremely effective in certain home-defense scenarios. However, their limited tactical penetration that gives these loads an advantage in many scenarios becomes a serious disadvantage in other scenarios."