test. from amino acid..

Discussion in 'Fitness & Nutrition' started by synthetic, Mar 25, 2010.

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  1. synthetic

    synthetic New Member

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    Background
    D-Aspartic acid is an amino acid present in Neuroendocrine tissues, invertebrates and vertebrates, including rats and humans. Here we investigated the effect of this amino acid on the release of LH and testosterone in the serum of humans and rats. Furthermore, we investigated the role of D-aspartate in the synthesis of LH and testosterone in the pituitary and testes of rats, and the molecular mechanisms by which this amino acid triggers its action.

    Methods
    For humans: A group of 23 men were given a daily dose of D-aspartate (DADAVIT ®) for 12 days, whereas another group of 20 men were given a placebo. For rats: A group of 10 rats drink a solution of either 20 mM D-aspartate or a placebo for 12 days. Then LH and testosterone accumulation was determined in the serum and D-aspartate accumulation in tissues. The effects of D-aspartate on the synthesis of LH and testosterone were gauged on isolated rat pituitary and Leydig cells. Tissues were incubated with D-aspartate, and then the concentration (synthesis) of cGMP in the pituitary and LH and of testosterone and cAMP in the Leydig cells was determined.

    Results
    In humans and rats, sodium D-aspartate induces an enhancement of LH and testosterone release. In the rat pituitary, sodium D-aspartate increases the release and synthesis of LH through the involvement of cGMP as a second messenger, whereas in rat testis Leydig cells, it increases the synthesis and release of testosterone and cAMP is implicated as second messenger. In the pituitary and in testes D-Asp is synthesized by a D-aspartate racemase which convert L-Asp into D-Asp. The pituitary and testes possesses a high capacity to trapping circulating D-Asp from hexogen or endogen sources.

    Conclusion
    D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats.



    So who is gonna abuse this latest find?

    but wait theres more!!

    there is an enzyme that can convert L-aspartic acid to D-asp.

    http://www.ergo-log.com/dasparticacidtestosterone.html

    Where is L-asp found? aspartame .. which is broken down into l-asp and L-phenylalanine (which is turned into mentol, a toxin)

    soo... aspartate racemase supp + bunch of splenda packets = increased test.

    discuss.
     
  2. tbizzle

    tbizzle you smoke that shit?

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  3. daballer2005

    daballer2005 New Member

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    816 up in this bitch
    ya there was an MD article on this cpl issues ago. there's only one company with a product out.

    not worth the money tho, skip the middle man and just get test
     
  4. themolsen

    themolsen New Member

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    $25 for 80 grams isn't worth the money?
     
  5. ErwinRommel

    ErwinRommel New Member

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    shut up with the science crap and link me to where i can get huge fast
     
  6. Hannibal King

    Hannibal King OT Supporter

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    .
     
  7. Thomas Crenshaw

    Thomas Crenshaw New Member

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    what are the side effects and all that bullshit? is it bad for your testicles if they are working at abotu 33% harder to produce the test?
     
  8. synthetic

    synthetic New Member

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    yep. your body is a system.. it will perform an opposite action to counter excess
     
  9. Finest

    Finest OG #93

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    Fuck that.
     
  10. Thomas Crenshaw

    Thomas Crenshaw New Member

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    like?
     
  11. synthetic

    synthetic New Member

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    d-Aspartic acid induced oxidative stress and mitochondrial dysfunctions in testis of prepubertal rats

    Abstract Previously we demonstrated the potential of d-aspartic acid (d-Asp), an acidic amino acid to induce oxidative response in prepubertal rat testis in vitro. In the present study, we determined the extent of oxidative stress in the testis of prepubertal rats that were administered d-Asp (100 and 500 mg/kg bw/d, i.p. 7 days). d-Asp treatment significantly elevated the levels of reactive oxygen species, malondialdehyde and hydroperoxide in cytosol and mitochondria of testis, which were accompanied by enhanced glutathione levels, elevated activities of glutathione-dependent enzymes and catalase suggesting a state of oxidative stress. Further, the activities of d-aspartate oxidase and 3β-hydroxy steroid dehydrogenase were elevated in the testis. The testis mitochondria of d-Asp-treated rats showed altered citric acid and complex enzyme activities, reduction in membrane potential, increased permeability and intracellular Ca2+ levels. Collectively, these findings suggest the potential of d-Asp to induce oxidative perturbations in the testis of prepubertal rats and this mechanism may in part be responsible for the observed physiological effects
     
  12. el es dee

    el es dee ...through a cloud of chalk and the midst of pain.

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    Its interesting for pct
     
  13. Thomas Crenshaw

    Thomas Crenshaw New Member

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    maybe you know what the fuck that all means. but how about us average folks....


    englishmotherfuckerdoyouspeakit
     
  14. Psyc0

    Psyc0 TTKA

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    That would probably be its best function. Help your body get back to normal by forcing the testes to work harder.
     
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