In reguards to #4: 4. Shot placement > Caliber. You can debate this all you want, but guess what caliber holds the record for most deaths in this country every year.. 9mm? Nope. .40? Nope. the big bad .45? Nope. It's the .22LR. I agree that shot placement is most important. However, does anyone actually carry something like a .22? What about a .38 even? For a lot of people the larger calibers seem to be a false sense of security, and I'm trying to prove this point to my girlfriend. She wants to get a gun and I'd like her to get a .38 I think.