Does Prozac cause a noticeable increase in blood pressure? I've had my blood pressure taken recently at a doctor's office and it was around 140/110. I took it on monday and it was 131/113. I took it right now and it was around 161/117! It's not like I'm lazy either. I go to the gym for a little over an hour on a regular basis. I lift weights and do cardio on the treadmill. I haven't eaten junk food like McDonalds on a regular basis since about three years ago. I don't remember my blood pressure being this high before taking Prozac. The doctor who prescribes the medicine for me told me that my social anxiety disorder could be causing my blood pressure to go up, but I don't really remember it being this high before I started seeking help for the disorder.