MGF/IGF-IEc

Discussion in 'Fitness & Nutrition' started by Jam_Master_J, Sep 26, 2006.

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  1. Jam_Master_J

    Jam_Master_J New Member

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    MGF/IGF-IEc the new hotness

    Any of you big dogs played ginea pig and have expierience with MGF or know anyone who has given it a whirl? If it is what it's cracked up to be :noes: . Interesting read regardless of your stance on the subject.


    MGF/IGF-IEc Profile

    Quick summary: MGF is a splice variant of the IGF produced by a frame shift if the IGF gene. It exhibits local effects in skeletal muscle and without modification is not systemic (can’t travel through the body). MGF increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells. This is a process required for adult muscle cells to continue growing.

    Complete Overview of MGF or IGF-IEc

    From its sequence, MGF is derived from the IGF-I gene by alternative splicing and has different 3' exons to the liver or systemic type (IGF-IEa). It has a 49 base pair insert in the human, and a 52 base pair insert in rodents, within the E domain of exon 5. This insert results in a reading frame shift, with a different carboxy (C) terminal sequence to that of systemic IGF-IEa. MGF and the other IGF isoforms have the same 5' exons that encode the IGF-I ligand-binding domain. Processing of pro-peptide yields a mature peptide that is involved in upregulating protein synthesis. However, there is evidence that the carboxy-terminal of the MGF peptide also acts as a separate growth factor. This stimulates division of mononucleated myoblasts or satellite (stem) cells, thereby increasing the number available for local repair

    During the early stage of skeletal muscle development, myoblasts (muscle stem cells) fuse to form syncytial myotubes, which become innervated and develop into muscle fibres. Thereafter, mitotic proliferation of nuclei within the muscle fibres ceases. However, during postnatal (after development) growth, additional nuclei are provided by satellite cells (myoblast) fusing with myotubules. Muscle damage-recovery seems to have a similar cellular mechanism, in that satellite cells become activated and fuse with the damaged muscle fibres (reviewed by Goldring et al. 2002). This is also pertinent to certain diseases such as muscular dystrophy in which muscle tissue is not maintained and which have been associated with a deficiency in active satellite (stem) cells (Megeney et al. 1996; Seale & Rudnicki, 2000) and in myogenic factors (Heslop et al. 2000). Skeletal muscle mass and regenerative capacity have also been shown to decline with age (Sadeh, 1988; Carlson et al. 2001). The reduced capacity to regenerate in older muscle seems to be due to the decreased ability to activate satellite cell proliferation (Chakravarthy et al. 2000). The markedly lower expression of MGF in older rat muscles (Owino et al. 2001) and human muscle (Hameed et al. 2003) in response to mechanical overload has been associated with the failure to activate satellite cells, leading to age-related muscle loss (Owino et al. 2001). Your muscle cels can not grow once they have reached a certain size unless they obtain more nuclei from the myoblast. MGF increases the myblast available to donate their nuclei to the adult muscle cell.
    “MGF appears to have a dual action in that, like the other IGF-I isoforms, it upregulates protein synthesis as well as activating satellite cells. However, the latter role of MGF is probably more important as most of the mature IGF-I will be derived from IGF-IEa during the second phase of repair. Nevertheless, it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introduced by intramuscular injection. This resulted in a 20 % increase in the weight of the injected muscle within 2 weeks, and the analyses showed that this was due to an increase in the size of the muscle fibres (Goldspink, 2001). Similar experiments by other groups have also been carried out using a viral construct containing the liver type of IGF-I, which resulted in a 25 % increase in muscle mass, but this took over 4 months to develop (Musaro et al. 2001). Hence, the dual role MGF plays in inducing satellite cell activation as well as protein synthesis suggests it is much more potent than the liver type or IGF-IEa for inducing rapid hypertrophy.”

    These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above.

    Methods of use:
    MGF inhibits differentiation, which is the actual fusing of the myoblast to the myotubule. So to optimize the effects of this one would want to try and take the MGF in a manner that differentiation would not be effected post work out.
    With the original version of MGF, it is only stable in your system for 12-24 hours. So taking it the day before a workout would provide sufficient time for the MGF to wear off.

    If one wanted to maximize the effects of MGF they could stack it with something that increased differentiation. In the case of IGF, the would want to take this on days they don't take MGF, or in the case of AAS it would depend on the types of AAS and the esters.


    Some sample MGF/IGF protocols
    3 day HST method
    MGF sun, tue, thur
    IGF mon tue wed (workout days)

    4 day split
    Sun MGF upper body
    Monday MGF lower body IGF upper body
    Tue IGF lower body
    Repeat thur/fri

    5 day split
    B/C MGF is not stable in the bloodstream, it will not effect the muscle you don't inject. So as long as you are using the original MGF you could inj MGF and IGF on the same days without worrying about conflicts b/t the peptides.
    Just inj the MGF in the muscle you will owrk the following day.


    CLIFFS: MGF growth hormone get yeild a localized increase in muscle mass when injected intra-muscularly.
     
    Last edited: Sep 27, 2006
  2. Marijuanair

    Marijuanair Remember to have your pet spayed or neutered! OT Supporter

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    they both have the potential to give you the "gh gut/insulin gut" where either your organs grow, or they get a fatty build up on them increasing their mass and pushing against your abdominal wall. I assume this is only a real problem with abusive body builders and not light use.

    I know any growth hormone had to be taken for about 6-9 months to see real results, the plus side is that they are gains you keep after your cycle, unlike gear where you can lose some/all of it back.

    IGF-1 sounds cool because it's both for bulking and cutting. I've been thinking of dableing with this one, but it's so damn expencive :(
     
  3. Marijuanair

    Marijuanair Remember to have your pet spayed or neutered! OT Supporter

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    When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue, IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.


    -quote on it from a large peice.
     
  4. Titus

    Titus New Member

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    you can get igf pretty cheap now...
     
  5. Marijuanair

    Marijuanair Remember to have your pet spayed or neutered! OT Supporter

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    the cheapest I've ever seen it is $100/ml
     
  6. Titus

    Titus New Member

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    i've seen as low as 70 not long ago. how long are you planning to run it anyway? not like you need a whole lot..compared to hgh, ifg is cheap as hell
     
  7. Marijuanair

    Marijuanair Remember to have your pet spayed or neutered! OT Supporter

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    I dont really know alot about it, I've read a few articals, and an e-book I read called "the HGH mirical" (something like that) talked about it. I had no real desire to dabble in insulin but was thinking about it recently as I explore my chemical enhancement options. I dont need anything, especally yet, so i'm just doing my research. I like to read, that's all I do now in my free time on my breaks at work.
     
  8. Jam_Master_J

    Jam_Master_J New Member

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    Werd on the IGF and GH gut ect, but the MGF is supposed to be injectin site specific elliminating the Body wide groth like IGF, As I understand it. A guy I know (who is chasing his pro card) just started taking the shit, I'm curious to see the results.
     
  9. methusala

    methusala New Member

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    I love how the Cliffs directly contradict the article. The article states that a 20% increase in muscle weight will not occur with IM injection. The real take home message is that MGF is localized whereas IGF is not.
     
  10. Marijuanair

    Marijuanair Remember to have your pet spayed or neutered! OT Supporter

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    MGF is for site specific increases, and IFG is for full body... I didnt even read the artical but if this is the cliffs he gave then they are correct.
     
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