There's nothing in the middle to focus on except two hands which are moving up and down. Yes, you can use all focus points but good luck getting the camera to lock onto the two subjects before the handshake is over. Just a small observation from covering a closing ceremony today. (Actually, I've known that handshakes are annoying, but I felt like bitching about it tonight because I need a break from going through ~ 3,500 pictures). EDIT: And for me, focus and recompose isn't always the best option (Although it's what I usually end up doing) because I like to shoot at the largest aperture appropriate.