F&N's Noob Guide to Steroids

Discussion in 'Fitness & Nutrition Archives' started by Filmboy44, Jan 16, 2006.

  1. Filmboy44

    Filmboy44 Guest

    Ok, boys and girls...with all of the "gear" threads and those that have been working out for a while and thinking of jumping to the "darkside" and don't knwo where to turn; I've decided to give you a little info on whats what, whats where and the hows of gear.

    Disclaimer: most of this info was forwarded to me by a member of another board, so I can't take credit for this write up. I have however added my two cents and changed a few things

    First and foremost, consult your physician-not everyone is comfortable with telling their doctor they use or are about to use roids and that is up to you but DO get a physical and have blood work done.
    Workout naturally for as long as possible-building a good solid base and foundation is important to your growth and maintaining gains after a cycle.
    Don’t start too young-it’s easy to want to jump on gear (steroids) when you’re in high school but don’t do it. Workout naturally and let your body develop as it should. Unless you’re competing wait until mid 20’s or so to start juicing, and have years of natural training already under your belt.

    Know your steroids-when you have settle on a particular cycle, know what it is you’re taking and the potential side effects. If it’s a steroid that’s hard on the liver, cholesterol, prostate, heart, kidneys, gyno prone, etc…know this and take measures ahead of time. The Afstore is LOADED with goodies to help combat these things.

    Starting-have all of your gear, ancillaries and post cycle therapy (PCT) before you start! It happens frequently where a bro will run out of his gear and not know what to do, or will panic because they start to experience signs of gyno (gynocomastia-bitch tits) and don’t have any anti-e’s (anti-estrogens) on hand. BE PREPARED!

    Cycle-this advice may vary from person to person and is only a guideline but this is what I usually recommend: I usually say to start with a 10 week cycle of a long ester testosterone(cypionate, enanthate, sustanon) at a dose of 400-500 mgs. per week. These should be broken up in to 2 shots a week. As an example: 200-250 mgs. Every Monday and another 200-250 mgs. Every Thursday. By shooting twice a week, it will help keep your blood levels more consistent. This isn’t necessary as you could shoot the whole 500 mgs. once a week but it seems more beneficial from a body building perspective to run it twice a week. Running this will give you an idea of how your body will react to testosterone and if you encounter any side effects. If you were running a stack (2 or more steroids at once) and had some negative side effects, you might not know which one was causing it. Testosterone is used as a base for a lot of cycles so this is important. Your PCT is what you will run after your cycle is complete to help get your natural testosterone up and running quickly in hopes of keeping gains acquired will on cycle. The timing of your PCT is important and the start date will vary depending on the half-life of the drug. So on this site, this is what it would look like:

    wks 1-10 test @ 400-500 mgs.
    wks 12-15 pct

    Consult your physician- After your cycle, check with your doctor to make sure all is well. Have more blood work done for a comparison.

    Once you’ve successfully completed your first cycle, you’ll probably be anxious to start another one. I know I was, so the question becomes: How long do I have to wait between cycles? Well, the general rule of thumb is that time on=time off. So if you were on a 10 week cycle, you’d wait 10 weeks after the completion of your PCT before you’d start your next cycle. Again, this is a guideline.

    When can you expect to see results? With this 10 week cycle, and with a lot of long ester cycles, usually around the 4th or 5th week.

    You want to know how much weight you can expect to gain from your first cycle, right? Well that’s all going to depend on a few things like your genetics, diet, workout and rest habits. A testosterone only cycle might get you 8 lbs. or it might get you 20 lbs. Experiment to find out. It’s a trial and error type of thing.

    How much of your gains will you keep after your cycle? Hard to say. Some believe that if you are already at your “genetic limit” than anything above that you won’t keep, or is difficult to keep. Some feel that a cycle will help you get to your genetic limit quicker and once there, you can maintain what you’ve gained. Don’t be surprised though if you gain 10-15 lbs. your first cycle and lose most of it. If not, great!! If so, maybe there are some adjustments you need to make. Trial and error.

    Testosterone is testosterone is testosterone! Test is test! It’s the esters that are added to them that are different. Example: testosterone propionate, referred to as prop and testosterone cypionate, referred to as cyp. They are both testosterones, however when the ester cypionate is added to test, it can be shot less frequently ( once or twice a week) than prop because it’s a much longer, slower acting ester (slower time release). Prop on the other hand is fast acting and requires frequent injections of every day or every other day.

    If you had a successful ride and would like to become a little more adventurous now, you can look in to stacking, or running a different cycle of a single steroid like anavar, or primo.

    This is probably a good place to put this…..WHat can have the biggest impact on your gains? Food. Plain and simple. Food. You are what you eat. You can add size to your frame with it, or you can “cut” with it. Your diet is crucial. Steroids can aid in achieving your goals of bulking or cutting but don’t expect them to do all of the work. You can use various steroids in a cycle to cut with or to bulk with. Some steroids don’t add much mass but will harden you up or make you more vascular which is why they are often suggested when cutting but if your diet isn’t in check, it’s not going to matter. And let’s not forget about the importance of water. Drink a lot of water everyday, whether on or off.

    Here’s some homework for you. Look these up, there are more but for now:

    17-aa steroids
    Half life
    Post Cycle Therapy

    A few sites to checkout:
    Afstore- http://www.anafit.com/shop
    Steroid Profiles
    Ancillaries- http://www.ag-guys.com
    Syringes- http://www.getpinz.com or http://www.ag-guys.com
    PCT calculator
    Steroid Scammer List

    Another link that I should've added:

    NEVER hesitate to ask a question! We all started at the beginning.
    Moderators on this board are here for a reason and are in that position for a reason. PLEASE DO NOT ASK FOR A SOURCE OR BUY/SELL.

    Definitions of Slang Terminology

    ALA= Alpha Lipoic Acid
    AS = Anabolic Steroids
    AR = Androgen Receptor
    BA = benzyl alcohol
    BB = Body Builder or Body Building
    BRO = You and I
    CASE = The body part of a syringe
    CC = cubic centimeter (one thousandth of a liter)
    CLEN = Clenbuterol
    CNS = Central Nervous System
    CYP = Testosterone Cypionate
    DART =Syringe/Needle
    DBOL = Dianabol (Methandrostenolone)
    DECA = Nandrolone Decanoate
    DHT = Dihydrotestosterone
    DNP = Dinitrophenol
    DRINK WINNY = Yes you can drink Winny
    ECA = Ephedrine/Caffeine/Aspirin
    ED = Every Day
    ENTH = Testosterone Enanthate
    EOD = Every other day
    EQ = Equipoise (Boldenone Undecylenate)
    FINA = Finaplix (Trenbolone Acetate)
    GEAR= steroids
    GH = Growth Hormone
    GHB = GAMMA HYDROXYBUTYRATE growth hormone
    GYNO = Gynomastica (Bitch tits)
    HGH = Human Growth Hormone
    HPTA = Hypothalamic Pituitary Testicular Axis
    IGF = Insulin Growth Factor
    INJ = Inject, Injection
    LH = Leutenizing Hormone
    MCG = Micrograms
    MG = Milligrams
    ML = Milliliters
    NYC = Norephedrine Yohimbe Caffiene
    NOLVA = Nolvaldex
    OTC = Over the counter
    PIN = Needle
    PRIMO = Primobolan, Primobolan Depot
    PROP = Testosterone Propionate
    SLIN = Insulin
    SUST = Sustanon
    T3 = Thyroid Hormone
    TEST = Testosterone
    TREN = Trenbolone
    WINNY = Winstrol-V (Stanozolol)
    17 AA = 17 Alpha Alkylated
    1cc = 1ml

    CRS = Can't remember Shit
    ot = off topic
    O/T = off topic
    LOL = Laugh out loud
    LMAO = Laughing my ass off
    LMFAO = laughing my fu(king ass off
    ROFLMAO = Rolling on the floor laughing my ass off
    ROFLMFAO = Rolling on the floor laughing my fu(king ass off
    ROFLMGDMFAO = rolling on the floor laughing my god damn mother fu(king ass off
    BTW = By the way
    IMO = In my opinion
    IMHO = In my humble opinion
    IMHO = In my honest opinion
    WTF = What the fu(k
    stfu = shut the fu(k up
    AAFLB = Accronims are for lazy bastards

    ED = Every day
    EOD = Every other day
    EQ = EQUIPOISE (Boldenone Undecylenate)
    Tren/Fina = Finaject (Trenbolone Acetate) ~ the old Parabolan
    Test = General expression for all testosteron, IE susta, propiante...
    HGH/HG = Human Growth Hormon
    d-bol/thai = Dianabol
    Winny/Win = Winstrol(Stanzolol)
    sust/omna = Sustanon/Omnadren
    Primo = Primobolan depot
    Clen = Clenbuterol
    ECA = Ephedrin/Coffein/Aspirin
    depot = injectable
    A-bombs/A50 = Anadrol 50
    frontload = More juice in the beginning of the cycle
    pyramid = most juice in the midle of the cycle. Little in the beg and end
    AAS/AS/roids/juice/gear = Anabolic Androgen Steroids
    MPB = Male Pattern Baldness
    gyno = gynomastic? (Bitch tits)
    PTC = Post cycle thearpy (Clomid, Nolvadex etc.)

    For many of you, this is common knowledge, but I'm sure that some of you still have a few questions about this subject. If you are new to steroids, this FAQ should answer your injection questions. We will start from the very beginning.......

    1cc = 1ml

    Gauge: The smaller the gauge, the thicker the needle. An 18g is much thicker than a 22g.

    Length: Generally 1.5" or 1" for our purposes.

    And yes, you can mix water and oil-based steroids in the same syringe.

    now we can proceed.......

    What is an intramuscular (IM) injection?
    A technique to deliver a medication into muscle tissue for it's eventual absorption into the systemic circulation. Steroids, both oil and water-based, are administered this way.

    What is a subcutaneous (sub-q) injection?
    A technique to deliver a medication into the soft tissue (fat) immediately underlying the skin. Insulin, HCG, and HGH are typically administered this way.

    What is aspiration?
    To aspirate is to withdraw fluid with a syringe. More specifically, after inserting the needle, pulling back on the plunger of the syringe for a few seconds to see if the needle is in a blood vessel. Rarely, this will be the case and a bit of blood will fill the syringe. If this happens the needle should be removed, replaced with a new one, and another injection site should be used. And yes, if there is a little blood in your syringe, it is ok to inject it along with your steroid once you have found a different spot..........it's your own blood isn't it?

    When aspirating, nothing should come back into the syringe if you are in the right spot. Pulling back on the plunger will create a vacuum in your syringe. The oil cannot expand to fill that space, but any air bubbles in your syringe will. You may notice the tiny bubbles getting bigger and bigger as you pull back. They will return to normal size as you release the plunger. If the air bubbles do not disappear upon releasing the plunger, you have an air leak most likely caused by the needle not being screwed onto the syringe tightly enough, although on very rare occasions, the syringe or needle itself can be defective. Either way, purge the air bubbles out, put a new needle on and try it again.

    Do I really need to aspirate?
    Those who inject without aspirating are taking unnecessary chances. Sweating, nausea, dizziness, severe coughing, breathing difficulties, anaphylactic shock, coma or death can all result from not aspirating. Most of the time, steroid users experience dizziness and coughing fits when they inject into a blood vessel. But you need to be aware of the dangers of neglecting this simple technique that should take about 3-5 seconds of your time.

    What exactly is an abscess?
    Abscesses occur when an area of tissue becomes infected and the body is able to "wall off" the infection and keep it from spreading. White blood cells migrate through the walls of the blood vessels into the area of the infection and collect within the damaged tissue. During this process, pus forms (an accumulation of fluid, living and dead white blood cells, dead tissue, and bacteria or other foreign invaders or materials).

    Abscesses can form in almost every part of the body and may be caused by bacteria, parasites, or foreign materials. Most of the time, it is caused by unsanitary injection techniques. On very rare occasions, it can be caused by foreign particles your gear (a greater chance of this occurs when using/making a homebrew). The abscesses that we are concerned about are usually reddish, raised, and painful.

    How do they treat an abscess?
    Antibiotics are often given to aid the cure of an abscess but the real cure is generally surgical. A doctor would open the thing up and allow the pus to drain, then the body would take care of the infection. Some have even gone so far as to "drain" their own abscesses by inserting a needle/syringe into the abscessed area and drawing out the accumulated pus, although this is not recommended.

    Can I reuse the same needle?
    Yes, but only if you are an idiot or cannot obtain anymore needles. There really is no need to explain why you shouldn't re-use a needle. Common sense should kick in here, but the bottom line of re-using needles is an INCREASED CHANCE OF INFECTION. If you have trouble obtaining needles in your area, try finding a different way of getting them. The hassle of finding a source is negligible compared to the hassle of the abscess in your ass that would most-likely require a doctor and a scalpel. There are methods to "sterilize" a needle for re-use, but I will not delve into them. If you are still considering re-using a needle, re-read the above two questions.

    Can I inject with the same needle I draw with?
    Yes, but it is preferable to switch the needle out with a new one. The needle dulls significantly when pushed into the rubber stopper of your vial or scraped along the bottom of your amp. You may not notice the difference if you inject into your glute, but try injecting into an area that has more nerve endings such as a delt or bicep and you will notice immediately.

    Does it matter if I push the needle in fast or slow?
    I would recommend slowly, but this is personal preference. A lot of people will tell you to jab the needle in quickly. These people usually stop that practice after the first time they hit a nerve going in at full speed (usually quad shots). By going in slowly, you'll have more time to react if you hit a nerve.

    Where exactly do I inject?
    A picture is worth a thousand words.

    What gauge needles should I use?
    for drawing - 20g, 21g

    18g needles are too big and they will eat up your stoppers in a hurry. A bigger hole means an increased chance of letting some little nasties into your sterile vial. Sometimes, the 18g will take out little chunks of rubber that fall nicely into your vial. That is not something you want. Imagine injecting that tiny piece of rubber into your muscle. I'll bet the doctor would have lots of fun digging into your muscle trying to find it and mutilating your muscle in the process.....

    for injecting - 22g, 23g, 25g - for oil-based steroids, 27g, 29g - for insulin, HCG, HGH, and some water-based steroids. 21g-25g for some lower quality types of winny or suspension, higher quality versions can use a smaller needle generally.

    22g and 23g are fine for glutes and quads. 25g is preferred for the smaller muscles such as delts, biceps, triceps, etc.

    What length needles should I use?
    Most people can get by with a 1" needle, but if you have a higher percentage of body fat or are just plain big you should use a 1.5" needle to insure that you get deep into the muscle. You should only use a 1.5" needle for glutes, or if you have huge quads. For smaller muscle groups, 1" is the most common, although some people like to use a 5/8".

    How many ccs can I shoot in one place?
    It depends on how big you are. A general guideline is 1cc for delts, 2cc for quads, and up to 3ccs for glutes. Some do more, some do less......it all depends. After a cycle or two, you will know what your body can handle. If you are injecting into other muscles such as biceps, triceps, or calves, it's best to start off with a small volume and work your way up.

    Can I pre-load my syringes?
    If at all possible, leave it in the vial or amp. If you need to pre-load, just keep in mind that the syringe must be stored safely. Nothing sucks more than having the plunger pushed in accidentally and losing some of your gear.

    Which is the best brand of needle?
    Terumo, B-D, and Monoject are the primary manufacturers of needles/syringes. Both Terumo and B-D have an ultra-thin wall design (the wall of the needle is thinner, so more fluid can pass through the same gauge of needle). From personal experience as well as opinions from many other steroid users, Terumo seems to be the sharpest.

    Common "FREAK OUTS"

    I can't get all the tiny air bubbles out of my syringe....
    As long as you tap it and get most of the air out, you will be fine. A little air intramuscular won't hurt you. According to the USH2 by Dan Ducaine, it supposedly takes about 10ccs of air injected into a blood vessel to kill you. I wonder how the hell they figured that one out.

    I saw blood in the syringe after I pulled out....
    You passed through a blood vessel and a little bit of blood entered the syringe on the way out. No biggie.

    I pulled the needle out and blood dripped/squirted out....
    You passed through a blood vessel. Apply a little pressure with your alcohol swab. You'll live.

    I pulled the needle out and oil was dribbling out....
    You injected too much in one place or you didn't inject deep enough. No biggie. Try injecting slower or leaving the needle in you for 30 seconds after you have injected it all. This should give the oil some time to dissipate so very little, if any, should dribble out.

    I injected into my quad, and my leg was twitching....
    You grazed a nerve. Usually it's a good idea to pull out and try another spot.

    I don't think I injected deep enough....
    If you think you injected into a layer of fat, don't worry. It will just take longer for the steroid to dissipate than it would if you had injected into the muscle. Eventually it will be absorbed. Don't let anyone tell you that you wasted it because that is not true.

    I want to mix two different steroids and combine them into one syringe. How do I do this?
    Let's say you want 1cc of deca and 1cc of test. First, draw 1cc of air and inject into your vial of deca. Withdraw 1cc of deca and pull the needle out. With the needle pointing up, draw 1cc of air into your syringe (your plunger will be at the 2cc mark - 1cc of deca in it and 1cc of air you just drew into it). With the needle pointing up, inject that 1cc of air into your vial of test. Withdraw 1cc of test. You now have 1cc of deca and 1cc of test in the same syringe. Don't forget to change the needle before you inject.

    Instructions for first-timers.....

    Step 1
    Wash your hands.
    Step 2
    Wipe the top of the vial of medication for injection with an alcohol swab.
    Step 3
    Remove the needle guard from the needle and syringe, saving the needle guard. Be sure you are using a proper syringe for intramuscular injections. Pull back on the syringe plunger to draw up an amount of air equal to the amount of medication that your doctor has prescribed for injection. For example, if you want to inject 2ccs of oil, then pull back 2ccs of air.
    Step 4
    Holding the vial of medication in an upright position, insert the needle straight through the center of the rubber stopper in the vial. Then push the plunger to discharge all the air into the vial.
    Step 5
    With the needle in the vial, turn the vial upside down and hold it in one hand. The tip of the needle should be in the solution. Using your free hand, pull the plunger back in a slow, continuous motion until you have drawn into the syringe the amount of medication that your doctor has prescribed.
    Step 6
    If air bubbles have formed in the syringe, dislodge them by gently tapping the syringe with your free hand while continuing to hold the syringe and vial in the inverted position. Bubbles should rise to the top of the syringe, and then you can push them back into the vial by moving the plunger. Double check to make sure you have the correct amount of medication in the syringe. If necessary, draw more solution into the syringe.
    Step 7
    Remove the needle from the vial. With the needle pointing upwards, pull back on the plunger until all oil from the needle has been pulled back into the syringe. Unscrew needle from syringe and replace with a brand new, preferrably smaller needle. Replace needle guard.
    Step 8
    Prepare the injection site by cleaning the area with an alcohol swab. To do this start at the center, apply pressure, and cleanse in a circular motion working outward. Do not retrace your steps.
    Step 9
    Wait a few seconds until the alcohol has dried. This reduces the sting. Remove the needle guard from the needle and syringe. With the needle pointing upwards, tap the syringe to dislodge the air bubbles and push the air out of the needle until you see a tiny drop of oil start to form at the tip. Hold the syringe as you would a pencil.
    Step 10
    Holding the syringe at a right angle (perpendicular) to the prepared injection site and insert the needle.
    Step 11
    When the needle is in place, slowly pull back on the plunger to see if any blood flows into the syringe. If some blood does enter the syringe (a rare occurrence), remove the needle, replace the needle with a new one, find another area to inject. Repeat Step 8.
    Step 12
    If no blood enters the syringe, slowly inject the medication by gently pushing the plunger until the syringe is empty.
    Step 13
    Remove the needle quickly. Apply pressure to the injection site with your alcohol swab. You're done. Massage the area. Now go do the most important parts - eat and train!

    Anabolic/Androgenic Steroids can be roughly classified into two types, oral and injectable. When you eat food or consume anything orally, the great majority of the ingested substances pass through the liver prior to entering the bloodstream. For this reason, "injectable" AAS cannot be taken orally because the liver will deactivate the steroids in this "first pass". Deactivation in the liver usually involves the addition of one or more hydroxyl (OH) groups to increase the solubility of the molecule in water, making excretion in the urine more easily accomplished.

    Oral Steroids
    Oral steroids involve modification of the parent steroid to make it harder for the liver to degrade the steroid molecules. This modification is almost always the addition of an alkyl (methyl) group at the 17 position of the steroid ring. The liver can still degrade the steroid, but not as effectively as the un-modified steroid. Therefore, oral steroids make several cycles through the bloodstream before being excreted. Most oral steroids are, to various degrees, excreted from the body unchanged.

    Injectable Steroids
    The injectable AAS are very effectively degraded in just a single pass through the liver. If this is so, then how can the injectables be effective? The answer is called a "depot" (or reservoir), which allows a regular release of steroid into the bloodstream. As steroid is removed from the bloodstream by the liver, more steroid is being released into the bloodstream from the depot. There are several ways to provide such a reservoir of the steroid.

    The first way is to use pure testosterone (a crystalline solid) suspended in water. Testosterone has a low solubility in water, and the crystals slowly dissolve in the watery environment of the tissue in which it is injected. The dissolved testosterone is carried throughout the body by the bloodstream. For Testosterone suspension, the "depot" is the actual physical site where the injection is made. The crystals do not migrate to other parts of the body, and the presence of the crystalline testosterone can cause some pain at the injection site. The testosterone dissolves at a (relatively) constant rate, and lasts for a few days in the body. Winstrol suspension is similar.

    The other way to provide a depot of steroid is to use a water-insoluble form of the steroid that can be converted in the body to the parent steroid, which has some solubility in water (bloodstream). Most commonly, the parent molecule is esterified with an organic acid, and the resulting ester is soluble in oil, but only very slightly soluble in water. Commonly used organic acid groups are acetate (C2), propionate (C3), enanthate (C7), decanoate (C10), and undecylenate (C11). The longer the carbon chain of the acid, the more oil-soluble the ester, and the longer it takes for the ester to turn into the parent steroid (de-esterification). A type of enzyme that is found throughout the body facilitates the de-esterification reaction to form the parent steroid from the ester. The enzyme actually catalyzes the reaction in both directions, so it can also attach an organic acid back onto the parent steroid. So, for example, testosterone enanthate can actually be turned into testosterone palmitate. There is some good evidence that steroid esters are, to some extent, stored in fat cells.
    It is commonly believed that esters form a depot of oil/ester that stays at the injection site. This is not true. While the depot concept holds true for esters (because they slowly release the parent steroid over time), the esters actually disperse throughout the body after injection, prior to (and during) the de-esterification reaction to form the parent steroid. They do not stay at the injection site. For example, the ester testosterone enanthate has been found in tissues throughout the body, including hair samples of subjects who have injected T200. If a bio-contaminant is introduced at the time of injection (non-sterile conditions), the body will attempt to encapsulate the contaminated material, and an abscess will form. In this case it appears as if the ester has remained at the injection site. But under normal sterile conditions, the oily solution will disperse. Injecting too much at one site or injecting too frequently at one site will not cause an abscess.

    Transport of Steroids in the Bloodstream
    Once the steroid has been released from the depot (or the oral steroid has been absorbed from the intestine), it is transported throughout the body in the bloodstream. Carrier proteins (Albumin and Sex Hormone binding Globulin) bind about 98% of testosterone under natural conditions. Thus, only 2% of the hormone is free to carry out its actions. When exogenous steroid is present, the level of free steroid is much higher than 2%. Bear in mind that the hormone is not permanently bound to the some of the proteins, but is constantly binding and un-binding from the protein. At any given time, about 2% of the hormone is un-bound in the natural state. So, if the 2% unbound hormone were to magically disappear, then the proteins would release more hormone such that 2% (of the remaining total) would come unbound. The bloodstream is the mechanism by which the hormones reach their target tissues (muscle).

    Action of Steroids

    Androgen Receptor Activation
    Once a free molecule of steroid reaches the muscle cell, it diffuses into the cell. The diffusion can be with or without transport-protein assistance. Once in the cell, the AAS is makes its way to the cell nucleus where it can bind with an androgen receptor (AR), and activate the receptor. Two of these activated receptor complexes join together to form the androgen response element (ARE). The ARE interacts with DNA in the nucleus, and increases the transcription of certain genes (such as muscle protein genes). As long as the ARE is intact, it accelerates gene transcription. Remember, though, that the AAS and the receptor are in a state of flux (binding and un-binding), just like with the Carrier proteins. So the ARE can be deactivated just by losing one of the two AAS that are bound to the AR's. This equilibrium situation explains why 1 gram per week testosterone is more effective than 1/2 gram per week, even though 1/2 gram appears to be more than enough to saturate all the AR's in the body. The higher concentration makes it more likely that the receptors will be occupied by an AAS, and the ARE will be intact for a longer period of time, on average.

    Other Actions
    Activation of the androgen receptor is a key mechanism in the action of AAS. However, this mechanism by itself does not explain the differences between steroids (i.e., nandrolone activates the AR better than testosterone, but is not as good of a mass-building product). Other actions involve primarily the central nervous system, and involve actions such as motor activation (muscle coordination) and mood (i.e., aggressiveness). The mechanism by which AAS effect these actions is not well understood at this time. Another effect occurs in the liver, where some steroids cause the release of certain Growth Factors. The different actions of the different AAS explains why a stack of two different types of AAS is often better than one by itself.

    Elimination of Steroids
    The liver is a primary route to deactivation of steroids, the chemical structure is changed here to make the steroid more soluble in water for excretion through the kidneys. A good portion of many steroids also are excreted as-is, without any alteration by the liver, or by formation of the sulphate, which is more water soluble. Many in the medical community have believed that AAS cause liver damage because levels of certain enzymes (AST and ALT) are elevated when steroids are used. Elevated levels of these enzymes are seen in patients with liver damage from other causes, so the conclusion is that AAS must cause liver damage because these enzymes are elevated. Recent work, however, has shown that a true marker of liver damage, GGT, remains unchanged when some AAS are used, and now it is questioned whether AAS are really damaging to the liver (the 17 alpha-alkylated AAS do cause damage in some rare cases, and this damage is reversible upon cessation of steroid use). The same thought processes were used to claim kidney damage, but that is unlikely as well.

    The Causes of Inhibition
    Elevated hormone levels, in general, will cause inhibition of natural testosterone production. What then besides estrogen can cause inhibition? DHT, which does not aromatize, has been extensively shown to cause inhibition of testosterone production. Androgen alone, then, is sufficient to cause inhibition. In Jim’s case, androgen use was moderately heavy, and androgen alone would seem the cause of the inhibition.

    Progesterone is another hormone that can cause inhibition, when used long-term. Paradoxically, in the short term it can be stimulatory. Other relevant factors include beta agonists, opiates, melatonin, prolactin, and probably other compounds. With the exception of beta agonists (e.g. ephedrine and Clenbuterol) and opiates (natural endorphins on the one hand being inhibitory, and Nubain blocking such inhibition) manipulation of these would not seem useful in bodybuilding.

    The Hypothalamic/Pituitary/Testicular Axis (HPTA)
    To understand inhibition of testosterone production, we need to know first how it is produced and how production is controlled. The broad general picture is that the hypothalamus receives a variety of inputs, for example, levels of various hormones, and decides whether or not more sex hormones should be produced. If the inputs are high, for example, high estrogen or high androgen or both, then it decides that little or no sex hormones should now be produced, but if all inputs are low, then it may decide that more sex hormones should be produced. It seems that the hypothalamus doesn’t respond only to current hormone levels, but also to the past history of hormone levels.
    The hypothalamus itself cannot produce any sex hormones – instead it produces LHRH, or luteinizing hormone (LH) releasing hormone, also called GnRH (gonadotropin releasing hormone.) This then stimulates the pituitary gland.

    The pituitary uses the amount of LHRH as one of its signals in deciding how much LH it should produce. Proper response depends on having sufficient receptors for LHRH. These receptors must be activated for LH to be produced. The pituitary also uses sex hormone levels, both current and the past history, in deciding how much LH to produce. Some aspects of the pituitary’s behavior are peculiar. For example, too much LHRH results in the pituitary downregulating LHRH receptors, with the result that very high LHRH production, which one would think should result in high testosterone production, actually lowers testosterone production. Another oddity is that while high estrogen levels inhibit the pituitary, still some estrogen is required to maintain a high number of LHRH receptors. So both very low and high levels of estrogen can inhibit LH production.

    LH produced by the pituitary then stimulates the testicles to produce testosterone. Here, the amount of LH is the main factor, and high levels of sex hormones do not seem to cause inhibition at this level.
    Inhibition From AAS Cycles
    Because high androgen levels sustained around the clock will cause inhibition, traditional cycles simply cannot avoid inhibition of LH production while on cycle. There are three ways to avoid it:

    · Avoid having high androgen levels around the clock. This can be done, for example, by using oral AAS only in the morning, with the last dose being approximately at noontime. Even 100 mg/day Dianabol can be used in this fashion with little inhibition. The problem with this approach is that gains are not very good compared to what is seen when high androgen levels are sustained around the clock.

    · Use an amount and kind of AAS that is low enough to avoid much inhibition. Primobolan at 200-400 mg/week may achieve this effect. Again, gains will be compromised compared to a more substantial cycle. Testosterone esters and Deca are substantially inhibitory even at 100 mg/week so using a low dose of these drugs will simply result in both inhibition and poor gains.

    · In principle, one could use an antiandrogen, but this would totally defeat the purpose of the cycle.

    Where AAS doses are sufficient for good gains, an interesting pattern is seen. For the first two weeks of the cycle, only the hypothalamus is inhibited, and it produces much less LHRH as a result of the high levels of sex hormones it senses. The pituitary is not inhibited at all: in fact, it is actually sensitized, and will respond to LHRH (if any is provided) even moreso than normally. After two weeks however, the pituitary also becomes inhibited, and even if LHRH is provided, the pituitary will produce little or no LH. This then is a deeper type of inhibition. After this point, there seems to be no definite further "switching point" where inhibition again becomes deeper and harder to reverse. As a general rule, I would say that there seems to be little difference between using AAS for 3 weeks vs. 8 weeks: recovery is about the same either way. Between 8 and 12 weeks, it becomes more and more likely that recovery will be difficult and slow, though even at 12 weeks it is common for recovery to not be too problematic, taking only a few weeks. Cycles past 12 weeks seem much more likely to cause substantial problems with recovery. In the hundreds of consultations I have done for people with recovery problems, very few (I can recall two) were for very short cycles such as 6 weeks, while most were for usages of 12 weeks straight or more.

    Cytadren: This drug can be used to reduce conversion of testosterone, Dianabol, and Equipoise (not an exclusive list of aromatizable AAS, but the main ones) to estrogen. Some feel that when estrogen levels are kept under control during the cycle, recovery is faster after the cycle is over, though that is not proven. It is a good idea though. And if testosterone esters were used prior to ending the cycle, some levels of these will remain for weeks, and continued use of Cytadren will help prevent conversion to estrogen, and thereby reduce inhibition. The best dosing pattern, in my opinion, is to take ˝ tab (125 mg) on arising, and then Ľ tab at six and 12 hours later. Use of more Cytadren than this, or a different pattern, may lead to an adverse effect on cortisol production, with subsequent cortisol rebound after discontinuing the drug. Some individuals suffer some lethargy (feeling of tiredness and laziness, or sleepiness) from Cytadren, but that is uncommon at this dose.

    Arimidex: This accomplishes the same purposes as Cytadren but without the possible side effects mentioned above. It is however far more expensive. A typical dose is 1 mg./day. The timing of the dosage does not matter, since the drug has a long half-life.
    Clomid: After a cycle is over, Clomid at 50 mg/day is usually very effective in restoring natural testosterone production. It acts by blocking estrogen receptors at the hypothalamus and pituitary. If androgen levels are not elevated, this is enough to cause production of at least normal amounts of LH, or often more LH than normal. During the cycle Clomid cannot prevent inhibition, though some think using it during the cycle will allow a faster recovery afterwards. That is not proven though. If nothing else, though, it is useful as an antigyno/antibloating agent during the cycle.

    Nolvadex: This works in the same manner as Clomid, but not nearly so well with regard to reversing inhibition. It is better to use this only as an anti-gyno/antibloating agent, if at all. If Clomid is used, there is no need for Nolvadex.

    HCG: This does nothing with regard to inhibition of the hypothalamus and pituitary. Rather it acts like LH, and causes the testicles to produce testosterone just as if LH were present. It is useful then for avoiding testicular atrophy during the cycle. The best dosing method is to use small amounts frequently: 500 IU per day is sufficient, and 1000 IU may optionally be used. The amount may be given as a single daily dose or divided into two doses. Administration may be intramuscular or subcutaneous. More is not better: too much HCG can result in downregulation of the LH receptors in the testes, and is therefore counterproductive. Overdosing of HCG can also result in gynecomastia.

    Ephedrine/clenbuterol: It is possible that the beta agonist activities of these drugs may assist in recovery. Personally, I do recommend the use of ephedrine post-cycle to those who can use it. Clenbuterol has the same effect but acts around the clock, having a longer half life, and allowing a higher effective dose (amount times potency) due to having less relative effect on beta receptors in the heart. I am not sure that clenbuterol has any better effect with regard to recovery though.

    Oral AAS: These do not assist recovery of natural testosterone production, but if used only in the morning, can help sustain muscle mass while in the recovery phase, with little or no adverse effect on recovery.


    Active Half-life of Steroids and Esters:

    Oral steroids Drug Active half-life
    Anadrol / Anapolan50 (oxymetholone) 8 to 9 hours
    Anavar (oxandrolone) 9 hours
    Dianabol (methandrostenolone, methandienone) 4.5 to 6 hours
    Methyltestosterone 4 days
    Winstrol (stanozolol)
    (tablets or depot taken orally) 9 hours

    Depot steroids Drug Active half-life
    Deca-durabolin (Nandrolone decanate) 15 days
    Equipoise 14 days
    Finaject (trenbolone acetate) 3 days
    Primobolan (methenolone enanthate) 10.5 days
    Sustanon or Omnadren 15 to 18 days
    Testosterone Cypionate 12 days
    Testosterone Enanthate 10.5 days
    Testosterone Propionate 4.5 days
    Testosterone Suspension 1 day
    * Winstrol (stanozolol) 1 day

    *Winstrol depot does not actually possess a classical half-life because it is un-esterified. Instead, the microcrystals dissolve slowly. Once they have all dissolved levels of the drug fall very rapidly. It is still an important consideration, and we have included it with a half-life of one day.

    Steroid esters Drug Active half-life
    Formate 1.5 days
    Acetate 3 days
    Propionate 4.5 days
    Phenylpropionate 4.5 days
    Butyrate 6 days
    Valerate 7.5 days
    Hexanoate 9 days
    Caproate 9 days
    Isocaproate 9 days
    Heptanoate 10.5 days
    Enanthate 10.5 days
    Octanoate 12 days
    Cypionate 12 days
    Nonanoate 13.5 days
    Decanoate 15 days
    Undecanoate 16.5 days

    Ancillaries Drug Active half-life
    Arimidex 3 days
    Clenbuterol 1.5 days
    Clomid 5 days
    Cytadren 6 hours
    Ephedrine 6 hours
    T3 10 hours

    A practical example is if one was to inject 100mg of testosterone propionate and allow blood levels to peak. In 4.5 days time (half-life duration from the above tables) and providing no other injections had taken place, the level would be reduced to 50mg. Again, a further 4.5 days down the line and levels would have dropped to 25mg, and the value keeps halving every 4.5 days
    Last edited by a moderator: Jan 16, 2006
  2. trancezj

    trancezj New Member

    Jul 17, 2002
    Likes Received:
    disclaimer: No asking about sources or attempting to purchase or sell please.
  3. MaineSucks

    MaineSucks Active Member OT Supporter

    Jan 5, 2005
    Likes Received:
  4. texchef

    texchef Guest

    Wow, that is a lot of work and too much to remember.

    Thanks for the info.
  5. Filmboy44

    Filmboy44 Guest

    well its here for your reference
  6. ralyks

    ralyks New Member

    Feb 22, 2005
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    Nice post. I thought (from what I've read) nolvadex was preferred over clomid.
  7. jonno

    jonno New Member

    Jun 3, 2003
    Likes Received:
    fort sam
    cool - thanks
  8. kopetzki

    kopetzki Banned

    Jun 24, 2005
    Likes Received:
    Jacksonville FL
    thanks for the write up, i copy-pasted it for future reference :o
  9. PurEvl

    PurEvl going out gassed and not half assed...

    May 15, 2002
    Likes Received:
    in a BFI container down an alley
    ahh i would check with fazle on this one...most drug/illegal is in the AH an even most in there gets dealt with.I have no problem with this but some may who own or run the site
  10. Filmboy44

    Filmboy44 Guest

    I figure that since its informative and can help those that get perscrtiptions from doctors. This is not recommnded for recreational use.
  11. KingLouis

    KingLouis Al Capone with a badge

    Jan 8, 2005
    Likes Received:
    Sydney, Australia
    Thanks filmboy.

    Bulknutrition's anabolic forums also has some nice stickied threads on the basics of steroids.
  12. trancezj

    trancezj New Member

    Jul 17, 2002
    Likes Received:
    I think it's fine for now. Like I say until someone tries to sell or buy.
  13. AaronOC

    AaronOC Guest

    nice article filmy
  14. trancezj

    trancezj New Member

    Jul 17, 2002
    Likes Received:
  15. nathanbx

    nathanbx New Member

    Sep 23, 2002
    Likes Received:
    Peoria, Il
    except poor palmer :wtc:
  16. I ordered two vials of progesterone :bigthumb:
  17. Ceaze

    Ceaze https://hearthis.at/DoYouEvenUplift Moderator

    Jun 4, 2000
    Likes Received:
    if you need steroids to make gains then you're weakminded
  18. trancezj

    trancezj New Member

    Jul 17, 2002
    Likes Received:
    :rofl: :rofl:
  19. Phineas Q Stork

    Phineas Q Stork Active Member

    Aug 22, 2003
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    What if you take mind enhancing steroids?
  20. AaronOC

    AaronOC Guest

  21. KingLouis

    KingLouis Al Capone with a badge

    Jan 8, 2005
    Likes Received:
    Sydney, Australia
    :werd: and Michelle too :wtc: :wtc: :wtc:
  22. brettD

    brettD New Member

    Dec 4, 2004
    Likes Received:
    good post,how many cycles have you down filmy
  23. Icuradik

    Icuradik Guest

    Im too skemish of needles to ever take steroids... :eek3:
  24. Filmboy44

    Filmboy44 Guest

    did you not read the thread? there are orals and liquids
  25. Dunken

    Dunken Welcome to the team.

    Dec 24, 2001
    Likes Received:
    Tempe, AZ
    nice adrenaline rush.

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