THE NEW NEW SPECIAL @ www.theafstore.com Begins 5/14/09 at 12am eastern Free PureCEE 60ct with any purchase over 40$ AS ALWAYS YOU MUST PUT OTFN in the CUSTOMER NOTES ------------------------------------------------------------------------------- The Estrogen Series: Part I Estrogen and Adiposity: the Vicious Cycle Estrogen is a necessary hormone but in excess it causes a host of issues. In this series of articles we will look at how excess estrogen and estrogenic compounds cause problems and what can be done about it. Estrogen and Fat The link between estrogen and body fat is circular. As body fat increases so does production of the aromatase enzyme; the enzyme that converts other hormones to estrogens. Increased production of the aromatase enzyme increases the amount of estrogen produced. As levels of estrogen increase, the amount of fat stored increases and the body’s ability to burn those fats decreases. This relationship leads to large stores of fat that are difficult to burn and produce more of the estrogen producing aromatase enzyme, which sustains the high levels of estrogen. Breaking the vicious cycle of high estrogen and body fat, even with exercise and diet, often proves to be difficult without directly addressing the cause and impact of high estrogen. Subcutaneous or peripheral body fat, also referred to as gynoid or female pattern fat, is a heavy producer of the aromatase enzyme. Areas where this type of fat is most prevalent are hips, chest, thighs, lower back and triceps. It is important for the purposes of this discussion to differentiate between estrogenic fat and androgenic fat stores. Androgenic fat stores are intra-abdominal (inside the belly) and these type of fat stores are almost devoid of the production of aromatase enzyme. If you have man boobs, you have estrogen issues. If you have jiggly thighs or cellulite, you have estrogen issues. If you have difficulty putting on muscle and libido issues you likely have estrogen issues, you may also have prolactin issues. Basically if something it seems unmanly then estrogen and possibly prolactin are at play. The aromatase enzyme, as mentioned above, converts other hormones to estrogens. It converts androstenedione, which is also a precursor to testosterone, to the weak estrogen metabolite estrone. Aromatase enzyme also converts the weak estrone and testosterone to the potent estrogen estradiol. This is significant because excess aromatase enzyme not only increases total conversion to estrogens, but it significantly increases the production of the stronger estrogen metabolite estradiol. Having more of the strong estrogen metabolite is highly linked to various “female” cancers, heart disease, prostate cancer and other health issues so this is not a good thing. These problems are all in addition to the negative impact that extra estradiol has on fat storage. In men, excess aromatase enzyme and subsequent estrogen production leads to the emergence of a female fat pattern as well as possible gynecomastia. Also, because more estradiol is being produced it enhances the negative feedback on testosterone production, not only making a man more female but less male. In women, aside from the very apparent fat storage issues, the increases in estradiol over estrone means more of the negative health effects like the various cancers and heart disease that are linked to strong estrogenic signaling. Basically this means less estrone, which is the relatively beneficial weak estrogen, and more estradiol which is the strong and relatively harmful estrogen. Estrogens direct impact on body fat is primarily, at least for the purposes of discussing estrogenic fat, through the regulation of adrenoceptors. Estrogens, and estradiol in particular, upregulate the alpha2 adrenoceptors and also down regulate beta adrenoceptor activity. In the simplest terms when it comes to body fat and its utilization for energy (fat burning), the beta adrenoceptors are the gas pedals and the alpha 2 receptors are the brakes. Estrogen, in those terms, enhances the brake pedal and weakens that gas pedal on your fat burning. In the race to lose fat or stop from gaining it, high estrogen puts you in the slow lane at best. There are three primary methods of interrupting or diminishing the effects of this cycle of estrogen, body fat and the aromatase enzyme. The first is to lose body fat through exercise and diet. Less bodyfat and less "fed" fatty tissue will produce less aromatase. The second is to block the alpha adrenoceptors with alpha adrenoceptor blocker like yohimbine. Blocking the alpha reduces the negative feedback that essentially shuts down site related fat loss/utilization. The third is to inhibit the aromatase enzyme either by blocking its synthesis, “destroying/using it up” with a suicidal aromatase enzyme inhibitor or by inhibiting its activity competitively with a competitive aromatase enzyme inhibitor. You have probably heard it a hundred times, and you are going to hear it again. In order to lose body fat you need a calorie deficit, eating fewer calories than you use. This usually means some kind of calorie restriction (aka. diet) and exercise program. Blocking the Alpha 2 adrenoceptor, while employing a calorie deficit, will significantly facilitate fat loss from estrogenic fat areas. By blocking the Alpha 2 you basically take the foot off the brakes, this will also allow the beta adrenoceptors to be more active so it’s a bit of extra foot on the gas pedal too. A topical yohimbine product like Yohimburn ES is really the best option because it delivers a high dosage of the blocking agent directly to the tissues that need it. Yohimburn ES delivers yohimbine to the tissue directly. Oral yohimbine just cannot achieve the tissue concentrations needed without causing significant side effects. Inhibiting the aromatase enzyme will take care of the estrogen production issue and will help with fat loss as well. At the time of this writing use of such inhibitors is only recommended in men, who will receive the added benefit of increased testosterone levels by inhibiting aromatase enzyme. Most aromatase enzyme inhibitors are prescription only. However, some over-the-counter products like AIFM have proven to be as effective as prescription aromatase enzyme inhibitors like aromasin. AIFM uses a natural suicidal aromatase enzyme inhibitor to “destroy”/inhibit the aromatase enzyme. Prescription aromatase inhibitors, like aromasin/exemestane and femera/letrozole, can be purchased for research. Some would consider this a grey market, others taking the right to purchase that should accrue with autonomy. www.researchstop.com provides a number of chemicals for research, including exemestane and letrozole as well as pramipexole (see below). Dopaminergics, whose primary use it to suppress prolactin, also suppress aromatase activity, ones that are commonly used include cabergoline (cabaser tablets only), pramipexole (also spikes GH levels) and selegiline. Excess estrogen production presents many issues, but there are means and tools to help combat this threat.