differences between CEE and creatine? *pic for your time*

Discussion in 'Fitness & Nutrition' started by gourmizz, Feb 26, 2010.

Thread Status:
Not open for further replies.
  1. gourmizz

    gourmizz New Member

    Joined:
    May 6, 2005
    Messages:
    14,844
    Likes Received:
    0
    Location:
    New York
    besides the obvious difference in the amount you ingest per serving, what are the pro's/cons/differences between the two?



    thanks bros :wavey:
    [​IMG]
     
  2. Ceaze

    Ceaze https://hearthis.at/DoYouEvenUplift Moderator

    Joined:
    Jun 4, 2000
    Messages:
    64,992
    Likes Received:
    690
    Biochem Biophys Res Commun. 2009 Oct 16;388(2):252-5. Epub 2009 Aug 4.

    Non-enzymatic cyclization of creatine ethyl ester to creatinine.

    Giese MW, Lecher CS.

    Department of Chemistry, Marian University, Indianapolis, IN 46222, USA. [email protected]

    Creatine ethyl ester was incubated at 37 degrees C in both water and phosphate-buffered saline and the diagnostic methylene resonances in the (1)H NMR spectrum were used to identify the resultant products. It was found that mild aqueous conditions result in the cyclization of creatine ethyl ester to provide inactive creatinine as the exclusive product, and this transformation becomes nearly instantaneous as the pH approaches 7.4. This study demonstrates that mild non-enzymatic conditions are sufficient for the cyclization of creatine ethyl ester into creatinine, and together with previous results obtained under enzymatic conditions suggests that there are no physiological conditions that would result in the production of creatine. It is concluded that creatine ethyl ester is a pronutrient for creatinine rather than creatine under all physiological conditions encountered during transit through the various tissues, thus no ergogenic effect is to be expected from supplementation.
    ____________________

    Biochem Biophys Res Commun. 2009 Aug 21;386(2):363-7. Epub 2009 Jun 12.

    Non-enzymatic hydrolysis of creatine ethyl ester.

    Katseres NS, Reading DW, Shayya L, Dicesare JC, Purser GH.

    Department of Chemistry and Biochemistry, The University of Tulsa, 800 Tucker Drive, Tulsa, OK 74014, USA.

    The rate of the non-enzymatic hydrolysis of creatine ethyl ester (CEE) was studied at 37 degrees C over the pH range of 1.6-7.0 using (1)H NMR. The ester can be present in solution in three forms: the unprotonated form (CEE), the monoprotonated form (HCEE(+)), and the diprotonated form (H(2)CEE(2+)). The values of pK(a1) and pK(a2) of H(2)CEE(2+) were found to be 2.30 and 5.25, respectively. The rate law is found to be Rate=-dCCEE/dt=k++[H2CEE2+][OH-]+k+[HCEE+][OH-]+k0[CEE][OH-] where the rate constants k(++), k(+), and k(0) are (3.9+/-0.2)x10(6)L mol(-1)s(-1), (3.3+/-0.5)x10(4)L mol(-1)s(-1), and (4.9+/-0.3)x10(4)L mol(-1)s(-1), respectively. Calculations performed at the density functional theory level support the hypothesis that the similarity in the values of k(+) and k(0) results from intramolecular hydrogen bonding that plays a crucial role. This study indicates that the half-life of CEE in blood is on the order of one minute, suggesting that CEE may hydrolyze too quickly to reach muscle cells in its ester form.
    ____________________

    J Int Soc Sports Nutr. 2009 Feb 19;6:6.

    The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels.

    Spillane M, Schoch R, Cooke M, Harvey T, Greenwood M, Kreider R, Willoughby DS.

    Department of Health, Human Performance and Recreation, Baylor University, Box 97313, Waco, TX 76798, USA. [email protected].

    ABSTRACT: Numerous creatine formulations have been developed primarily to maximize creatine absorption. Creatine ethyl ester is alleged to increase creatine bio-availability. This study examined how a seven-week supplementation regimen combined with resistance training affected body composition, muscle mass, muscle strength and power, serum and muscle creatine levels, and serum creatinine levels in 30 non-resistance-trained males. In a double-blind manner, participants were randomly assigned to a maltodextrose placebo (PLA), creatine monohydrate (CRT), or creatine ethyl ester (CEE) group. The supplements were orally ingested at a dose of 0.30 g/kg fat-free body mass (approximately 20 g/day) for five days followed by ingestion at 0.075 g/kg fat free mass (approximately 5 g/day) for 42 days. Results showed significantly higher serum creatine concentrations in PLA (p = 0.007) and CRT (p = 0.005) compared to CEE. Serum creatinine was greater in CEE compared to the PLA (p = 0.001) and CRT (p = 0.001) and increased at days 6, 27, and 48. Total muscle creatine content was significantly higher in CRT (p = 0.026) and CEE (p = 0.041) compared to PLA, with no differences between CRT and CEE. Significant changes over time were observed for body composition, body water, muscle strength and power variables, but no significant differences were observed between groups. In conclusion, when compared to creatine monohydrate, creatine ethyl ester was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power. Therefore, the improvements in these variables can most likely be attributed to the training protocol itself, rather than the supplementation regimen.
     
  3. gourmizz

    gourmizz New Member

    Joined:
    May 6, 2005
    Messages:
    14,844
    Likes Received:
    0
    Location:
    New York
    so basically, CEE doesn't work?
     
  4. gourmizz

    gourmizz New Member

    Joined:
    May 6, 2005
    Messages:
    14,844
    Likes Received:
    0
    Location:
    New York
    also, what creatines do you guys recommend?
     
  5. scream

    scream New Member

    Joined:
    Jun 2, 2009
    Messages:
    129
    Likes Received:
    0
    regular creatine mono works fine for most people. if it bloats you really bad you could try green magnitude by controlled labs, size on by gaspari or c-bol by thermolife.
     
Thread Status:
Not open for further replies.

Share This Page