Cabaser Causes Heart Valve Problems

Discussion in 'Fitness & Nutrition' started by DatacomGuy, Sep 11, 2007.

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  1. DatacomGuy

    DatacomGuy is moving to Canada

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  2. macro

    macro New Member

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    it does not cause heart valve regurg problems in people that use it for hyperprolactinemia, those cases were found in parkisons patients who use on average 6mg/day and after 6 months of treatment at those dosages. Highest end prolactin dose 2-3 weeks at 1mg followed by .5mg ed for a short period and generally .5mg eod or less thereafter. keeping in mind that there is about a 5 day half life the difference between 6mg and 1mg is TREMENDOUS.

    the issue arises from high concentrations of the drug wherein there is 5ht2 receptor binding, cabergoline has a very low affinity for 5ht2, but at high concentrations (like most ligands) it does bind.

    as a note- there were 12 cases out of 11,000+ patients, the link is not particularly strong either still looking at their data construct which seems very strange. The issue has been way overblown and there has been no link between prolactin treatment and this condition.
     
  3. MaineSucks

    MaineSucks OT Supporter

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  4. DatacomGuy

    DatacomGuy is moving to Canada

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    Other articles I've read say 1 in 4? I'll have to find on MSNBC.

    I was going to take .5 every other day.. still safe? 3mg a week..

    EDIT:
    http://www.msnbc.msn.com/id/16454843/#storyContinued

    Burn not found? We're here for information?
     
  5. Mass

    Mass Active Member

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    this is just like the whole "clen kills cardiac muscle in rats" saga that took place 2 yrs ago
     
  6. MaineSucks

    MaineSucks OT Supporter

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    I'm just fuckin witcha nigga

    [​IMG]
     
  7. macro

    macro New Member

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    from the very study that launched the law suits.

    "This risk was particularly high among patients who had taken daily doses of pergolide or cabergoline that exceeded 3 mg;the risk was increased only among those who had taken either drug for 6 or more months.”

    exceeded 3mg day for more than 6 months
     
  8. DatacomGuy

    DatacomGuy is moving to Canada

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    I know it. :rofl: @ smilie


    Interesting.
     
  9. JeremyD

    JeremyD New Member

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    Old news.

    Run it at .5mg E3D and you'll kill any prolaction issues with pretty much no sides. I still like cabergline though. Damn you Lyle McDonald!!!!
     
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