SRS Antidepressants and pregnancy?

Discussion in 'On Topic' started by Cerridwen, Aug 30, 2006.

  1. Cerridwen

    Cerridwen Guest

    Let me start off by saying I'm not seeking medical advice. I already have an appointment with my doctor to discuss all of the questions I have.

    What I am seeking is someone who has gone through this. I have dealt with depression since I gave birth to my daughter 9.5 years ago. I have basically been on antidepressants since then. I have attempted going off of them (both with and without a doctor's support) but it hasn't gone well. I am currently on busiprone and budeprion (one is the generic of Wellbutrin, the other is an anti-anxiety medication). I have done some research and there aren't too many facts out there regarding antidepressants and pregnancy. All I have found is that the risks are unknown. I need to find a different way to deal with my depression for the next 10+ months if at all possible.

    Any suggestions or advice? Questions I should make sure to ask my doctor?
     
  2. civicmon

    civicmon got all my game from the streets of california.

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    anecdotal... but I once read that due to all the hormonal shit that goes on during pregnancy, many people w/ severe depression wind up feeling alright during pregnancy.

    I very well may be wrong.. but i distinctly remember reading that.

    best of luck to you.. let us know how things are going :love:
     
  3. big 1

    big 1 New Member

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    Well, i would stop taking those drugs jsut based onthe fact that anythign you take your baby takes too. and your baby may/may not be depressed. bottom line if nothing is approved for pregnant/nursing mothers...stay away
     
  4. Peyomp

    Peyomp New Member

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    This is difficult, since actual depression will be harmful to the fetus as well. I would ask a doctor. Then ask another. Then another. In their office, on the phone, on the web. I'd research the shit out of it. I know you're not looking for medical advice, and I haven't been through this but its just my two cents. You should consider that actual depression is harmful to a fetus. I'd do research on the effects of depression during pregnancy, and possible side effects of the medicine and compare.

    Your options include exercise (definately), fish oil (might help)... lots of sun? If you're seriously predisposed, though... I dunno how much all that is gonna help. Pregnancy is an overwhelmingly stressful time, which would tend to trigger your depression.

    Tough spot.
     
    Last edited: Aug 30, 2006
  5. Cerridwen

    Cerridwen Guest

    That's pretty much how I feel. I know that being depressed during pregnancy cannot possibly be healthy, so any way I look at it my baby will be exposed to some sort of risks from either the depression or the medication. :hs:

    I have never really found another way to deal with my depression, but I have started excercising more and I'll have to check with the doctor about the fish oil. Thanks Peyomp. :)
     
  6. 7960

    7960 New Member

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    Horrible, horrible advice.


    Like you said you need to see your doctor. I have a friend who took her depression meds throughout her pregnancy and another who was told she *must* stop taking hers *before* she gets pregnant. Since I don't know what they were taking, and since your doctor will know better than anyone, ask her.
     
  7. Cerridwen

    Cerridwen Guest

    I have an appointment next week, I just wanted to start gathering some information and hopefully reading other's experiences before then. I am not pregnant yet, but I do want to do everything "right" in this pregnancy and not put my child through unecessary risks if at all possible. I am pretty confused on the subject to be honest. All of the information seems so very conflicting.
     
  8. Cerridwen

    Cerridwen Guest

    Ugh. I just broke the news to my mom and the first thing out of her mouth was you HAVE to stop taking Wellbutrin. She suggested that I talk to my doctor about switching to a different antidepressant, such as Prozac, where there have been studies done on pregnant women and they have concluded them to be relatively safe to use. I did find this also. http://www.womensmentalhealth.org/resources/faq_09-01-02.html
    Now I'm just nervous.
     
  9. Darketernal

    Darketernal Watch: Aria The Origination =)

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    Nothing to be nervous about. And in all honesty its a horrible moment to listen to your mother at this moment who has brought you more 'doubtfull moments' in your life to say the least. SO, stop listening to your mother and start listening to the doctors/experts on this. Even a consult with your house doctor could already bring some relief. Relax, take a deep breath. All with all there's no reason to panic , what you are searching for is reliable information. Its something you won't get from your mother, she is not a medical expert. And as such as a real medical expert for advice. Just wait out your appointment.
     
  10. Darketernal

    Darketernal Watch: Aria The Origination =)

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    An exerpt from womansmentalhealth.org

    Wellbutrin (bupropion) and Pregnancy

    Q. I have a long history of depression and have been taking Wellbutrin (bupropion SR) for several years now. Every time I try to come off the medication, the depression comes back. I am planning to get pregnant within the next year and was wondering if it is safe to use Wellbutrin.

    A. While there is information to support the use of certain antidepressants, including fluoxetine, citalopram and the tricyclic antidepressants during pregnancy, there are much less data on the reproductive safety of bupropion (Wellbutrin). Information from the manufacturer (GlaxoSmithKline) includes data from 426 pregnancies involving first trimester exposure to bupropion. In this sample, there were 12 outcomes that involved major malformations. This represents a 2.8% risk of congenital malformation, which is consistent with what is observed in women with no known teratogen exposure. While this information regarding the overall risk of malformation is reassuring, the most recent report revealed that 8 of the 12 cases reported involve malformations of the heart and great vessels. In addition, among the 16 retrospectively reported cases of malformations in bupropion-exposed infants, seven involved cardiac defects. While these reports may signal a potential risk, the manufacturers point out that the relatively small sample size and the high percentage of cases lost to follow-up (n=302) make it difficult to draw solid conclusions regarding the impact of bupropion on the developing cardiovascular system; further studies regarding the reproductive safety of this medication are warranted.

    Given the uncertainly regarding these findings, women may want to switch to the better characterized SSRIs or a tricyclic antidepressant. However, there may be certain situations when it is appropriate to use this medication during pregnancy. If a woman has had a poor response to SSRIs in the past but has had a good response to bupropion, one may consider re-initiating treatment with bupropion. This is done, of course in the context of an informed conversation between the patient and her doctor, acknowledging the lack of extensive information regarding its reproductive safety. It is important to remember that untreated depression in the mother is not benign and may place both the mother and her children at risk.

    Ruta Nonacs, MD, PhD



    Basically this comes down to that its best to stop taking wellbutrin during a pregnancy, and finding a well known anti-depression substitute of which the outcomes during pregnancy are better known. But all in all this is a medical question which has to be discussed with your medical expert/doctor.
     
  11. Cerridwen

    Cerridwen Guest

    :mamoru: I know that's the truth. I am just really anxious about everything, I'm not panicking or anything yet :o I just wish my appt. was sooner.
     
  12. hornet

    hornet New Member

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    This is a difficult issue and it will take careful work between you and your physician to decide what to do.

    Keep in mind that pharmaceutical "research" is largely funded by pharmaceutical companies, and the FDA (which regulates the pharmaceutical industry) receives some of its funding from the drug companies (can you say conflict of interest?). When drug reps claim that research studies show that their drug doesn't do harm to the patient (or fetus), you have to take it with a huge grain of salt.

    Depression can make your life miserable, and medication might help you. But it might not. You just have to get your dr. to prescribe something and see how it works.
     
  13. Cerridwen

    Cerridwen Guest

    Hornet, thank you for your thoughts, but I have been dealing with depression and have been on antidepressants for over 9 years now. It isn't about finding something and seeing how it works, it is about keeping my baby safe while I am pregnant and not losing my mind over it. :)
     
  14. big 1

    big 1 New Member

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    out of curiosity...and i dont mean to judge here...if youre depressed right now, and taking antidepressants that may have a slight chance of harming your baby (im trying to put this as respectfully as possible as so not to hurt ur feelings).why would you want to have a child right now?

    wouldnt it jsut be smarter to wait another year or two, until youve received treatment and/or completed school? some mothers experience "baby blues" after giving birth, and you might have a really haevy case of it, given youre clinically depressed......obviously its your choice if you want to try to have a child. but your husband , from teh sounds of it, loves you. i think hed be just as happy now as he would if you tried to have a kid in 2 years, when youre done school and possibly treated for depression.

    Im just saying it might be the best thing for you, your family and the child if you wait until you are emotionally financially and mentally healthy.....
     
  15. Cerridwen

    Cerridwen Guest

    big1, My daughter is 9.5 years old. This is more than just a case of the "baby blues". It started out as post-partum depression and hasn't gone away. I expect to be on medication for quite some time to come. Chances are waiting a couple of years is not going to change anything. I have a history of mental illness in the family (depression in my mother, grandmother, bi-polar in my little sister etc). I am not going to not have a very wanted child because I am dealing with a treatable medical condition. :)

    Financially we are fine. Nobody is ever truly ready financially to have a baby, but we can provide for one. Emotionally I am fine with my medication. We are a very stable family, and we have thought of everything that comes with having a baby. We have been together for 8-9 years and have been married for 6.5.

    I don't expect anyone to agree with our decision, and to be completely honest I am not looking for anybody's permission or approval. I appreciated your advice though, big1.

    BTW if you want to know why we decided to have the baby before I am done with school, see my post in Vag as it explains it there.
     
  16. ebbnflo

    ebbnflo REAL- LAOT Hermit

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    I just wrote you a big reply, and I got logged off. Dammit, I hate when I forget to copy before I send. ( insert 32 swear words here, rgh)

    So here are the cliffs because I am too lazy to rewrite it all. You can PM me if you'd like.

    I was on Effexor while PG with my 1st. I was referred to I THINK a perinatologist (It was a while back, so my memory is fuzzy) who spoke with me about what was known about Effexor and pregnancy. I chose to stay on it until after I had the baby and went off when she was a few months old, and tried a different med.

    I am on Welbutrin now, and it works better than anything I have tried over the years. I recently had a "scare" with a 61 day cycle, and was faced with a plethera of fears over the meds I am on currently, and the possibility of being pregnant. It turned out to be an ovarian cyst, but, having thought about it, I THINK I would have chsen to stay on the Welbutrin if I was pregnant. I am actually mulling over possibly trying for another baby sometime soon.... Just mulling it over, no decisions yet, but I am relatively sure that I would stay on the Welbutrin if I do get pregnant.

    I have suffered with depression for years and years myself, and I think it would probably be worse for me to go off the meds, than it would for me to remain on them during a pregnancy.

    It's a tough decision. I feel for you. Talk to a few docs, specialist in Mental Health, and Natology, and then make the decision that is best for you.
     
  17. Cerridwen

    Cerridwen Guest

    Ebbnflo, thank you for sharing your experience with me. We have decided (hubby and I) that there is not enough information out there on the effects on the fetus with Wellbutrin for me to stay on it. I will be requesting that my doctor switch my medication at my next appointment and hopefully it will work.
     
  18. S4Driver

    S4Driver New Member

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    You are on the right track with seeing your doctor soon. Bottom line is that most all medication that you will take gets to your baby. It is up to you and your doctor to decide what will work the best for you. I went through this very same thing with my gf while she was pregnant with our first child. I did a ton of research online and on the phone to make sure that we were as informed as possible.

    Without going on forever, (I think you will have a good conversation with your Dr.) there are a few points I can recall. Most SSRI's like Zoloft, Paxil, and Prozac hold risks for babies being born with respiratory problems. You also have to watch out for the class of drug that you are taking. This applies to all meds that you take though, not just for depression meds. I commonly found that it is a general rule to avoid most all medications, if at all possible, while you are pregnant unless they are medically necessary.

    My g/f ended up taking Buspar (sp?) while pregnant and while breast feeding, for a time. Good luck.
     

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