Anabolic steroid-induced hepatotoxicity: is it overstated?

Discussion in 'Fitness & Nutrition' started by michael, Nov 9, 2006.

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  1. michael

    michael FLORIDA > *

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    Anabolic steroid-induced hepatotoxicity: is it overstated?

    Dickerman RD, Pertusi RM, Zachariah NY, Dufour DR, McConathy WJ.

    The Department of Biomedical Science, University of North Texas Health Science Center, Fort Worth 76107-2699, USA.

    OBJECTIVE: There have been numerous reports of hepatic dysfunction secondary to anabolic steroid use based on elevated levels of serum aminotransferases. This study was conducted to distinguish between serum aminotransaminase elevations secondary to intense resistance training and anabolic steroid-induced hepatotoxicity in elite bodybuilders. DESIGN: This was a case-control study of serum chemistry profiles from bodybuilders using and not using anabolic steroids with comparisons to a cohort of medical students and patients with hepatitis. PARTICIPANTS: The participants were bodybuilders taking self-directed regimens of anabolic steroids (n = 15) and bodybuilders not taking steroids (n = 10). Blood chemistry profiles from patients with viral hepatitis (n = 49) and exercising and nonexercising medical students (592) were used as controls. MAIN OUTCOME MEASURES: The focus in blood chemistry profiles was aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (GGT), and creatine kinase (CK) levels. RESULTS: In both groups of bodybuilders, CK, AST, and ALT were elevated, whereas GGT remained in the normal range. In contrast, patients with hepatitis had elevations of all three enzymes: ALT, AST, and GGT. Creatine kinase (CK) was elevated in all exercising groups. Patients with hepatitis were the only group in which a correlation was found between aminotransferases and GGT. CONCLUSION: Prior reports of anabolic steroid-induced hepatotoxicity based on elevated aminotransferase levels may have been overstated, because no exercising subjects, including steroid users, demonstrated hepatic dysfunction based on GGT levels. Such reports may have misled the medical community to emphasize steroid-induced hepatotoxicity when interpreting elevated aminotransferase levels and disregard muscle damage. For these reasons, when evaluating hepatic function in cases of anabolic steroid therapy or abuse, CK and GGT levels should be considered in addition to ALT and AST levels as essential elements of the assessment.
     
  2. scent of a wookie

    scent of a wookie OT Supporter

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    :cool: but I have seen some bad blood tests, pur has stated he has had problems when he wasn't taking support
     
  3. michael

    michael FLORIDA > *

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    well i'm sure -- but the point of the study is to show that often the bad enzymes are being caused simply by weight-training and not by the steroids.. unless you test where these markers are coming from, you can't know if it's training-induced or steroid/liver-induced.
     
  4. bigdamray

    bigdamray New Member

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    Dickerman RD, he is a friend of mine!!
     
  5. MaineSucks

    MaineSucks OT Supporter

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    yeah, you like man dick dont ya, ray?
     
  6. bigdamray

    bigdamray New Member

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    Just from you big guy!!:greddy:
     
  7. MaineSucks

    MaineSucks OT Supporter

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  8. Steve325

    Steve325 Guest

    yes

    Liver damage is probably the most sensationalized of all side effects possible from steroid use. The media often focuses on this particular problem as if it occurs with every steroid, and in every person who takes them. Nothing could be further than the truth. Most anabolic steroids which are ingested orally pass through the liver, which functions as the body´s filtration system. When something goes through the liver, it is broken down by various enzymes, and passed along into the bloodstream. Most research on orally administered anabolic steroids focus on the fact that liver enzymes are elevated following ingestion. But does this necessarily mean that the liver is being damaged, does it? Of course not. Commonly, studies that focus on steroid toxicity often use absurd doses, or incorrectly focus on liver activity instead of damage. The liver functions as the filter for the human body.. it´s going to be activated whenever something (not just a steroid) passes through it. Does that show that steroids damage the liver? Let´s see what the scientists say..
    There was an eight-week study done in 1999, which looked at the effects of an 8-week cycle of Oral steroids. The steroids examined were Halotestin (Fluoxymesterone), Dianabol (methylandrostanolone), or Winstrol (Stanozolol) on rats at the dose of 2mg/kg-body weight, administered five times a week for 8 weeks. That s almost 200mgs/day of any of those steroids, for a 200lb user. That is, I´ll speculate, much more than the average person would use on a cycle. In fact, I have never, in my years of researching steroids and speaking with athletes, heard of anybody using 200mgs/day of Halotestin, Winstrol, or Dianabol. Ever.
    And, at the end of that study, In vivo, each rat still had liver enzyme levels that were within normal range!
    (*Med Sci Sports Exerc. 1999 Feb;31(2):243-50, Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Molano F, Saborido A, Delgado J, Moran M, Megias A.)
    In another study, 16 bodybuilders using steroids were compared to 12 bodybuilders who were not. Then the bodybuilders who had used steroids stopped taking them for three months, at which points, the researchers found that liver enzymes had returned to the same levels as the non users. After only 3 months!
    (*Int J Sports Med 1996 Aug;17(6):429-33, Body composition, cardiovascular risk factors and liver function in long-term androgenic-anabolic steroids using bodybuilders three months after drug withdrawal. Hartgens F, Kuipers H, Wijnen JA, Keizer HA.)
    We can see from the chart below that ex-steroid users have totally normal liver enzymes one year after they stop using& .in fact, for some liver enzymes, even the current users have normal scores!

    [​IMG]
     
  9. el es dee

    el es dee ...through a cloud of chalk and the midst of pain.

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    so what your all saying is that i need to be juicing?
     
  10. michael

    michael FLORIDA > *

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    nice article steve.. it would hold a little more water if it didn't seem like an 8 year old wrote it -- but I like the jist.
     
  11. michael

    michael FLORIDA > *

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    We're saying that if you did, you wouldnt shit out your liver after 3 days; even though the media would have you believe that you would.
     
  12. Steve325

    Steve325 Guest

    yeah thats steroid.com for you
     
  13. JeremyD

    JeremyD New Member

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  14. michael

    michael FLORIDA > *

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  15. scent of a wookie

    scent of a wookie OT Supporter

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    media blows everything out of proportion, espcially AAS :hsd:
     
  16. TXLBS

    TXLBS New Member

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    This is not a steroid board.
     
  17. Shiftknob

    Shiftknob New Member

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    pretty nice read.
     
  18. michael

    michael FLORIDA > *

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    you forgot Sticky:
     
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